24-Methyllanosta-7,25-dien-3-one
نویسندگان
چکیده
THE TITLE COMPOUND [SYSTEMATIC NAME: 17-(5,6-di-methyl-hept-6-en-2-yl)-4,4,10,13,14-penta-methyl-1,5,6,10,11,12,13,15,16,17-deca-hydro-2H-cyclo-penta-[α]phenanthren-3(4H,9H,14H)-one], C(31)H(50)O, is a triterpenoid which was isolated from Skimmia laureola. The three six-membered rings adopt chair, slightly distorted half-chair and distorted boat conformations, and the five-membered ring is in an envelope conformation. All the rings are trans fused. In the crystal structure, there is a weak C-H⋯O hydrogen bond.
منابع مشابه
Biotransformation of chenodeoxycholic acid by Pseudomonas species NCIB 10590 under anaerobic conditions.
The metabolism of chenodeoxycholic acid by Pseudomonas sp. NCIB 10590 under strict anaerobic conditions was studied. A range of unsaturated acidic and neutral metabolites were isolated and identified. The major acidic product was chola-4,6-dien-3-one-24-oic acid whilst the major neutral product was androsta-4,6-dien-3,17-dione. The major acidic products were 7 alpha-hydroxy-5 beta-cholan-3-oxo-...
متن کاملConcerning the role of lanosterol and cycloartenol in steroid biosynthesis.
An homogenate of rat liver which was capable of converting 2-3H-lanosta-8,24-dien-3fl-ol to 2-3H-cholest-5-en-3/3-ol failed to convert 2-3H-9, 19-cyclolanost-24-en-30-01 to 2-3Hcholest-5-en-3/3-01. However, both substrates underwent reduction at C-24,25. 2-3H-9, 19-Cyclolanost-24-en-3/?-01 was not converted to 2-3H-lanosta-8,24-dien-3P-ol. Both the presence and biosynthesis (from 2-14C-mevalona...
متن کامل{2,2′-[3-Azapentane-1,5-diylbis(nitrilomethylidyne)]dipyrrol-1-yl}(4-methylpyridine)cobalt(III) tetraphenylborate
The title compound, [Co(C(14)H(17)N(5))(C(6)H(7)N)](C(24)H(20)B) or [Co{(pyrrole)(2)dien}(4-Mepy)]BPh(4) where (pyrrole)(2)dien is 2,2'-[(3-aza-pentane-1,5-diylbis(nitrilo-methyl-idyne)]dipyrrole and 4-Mepy is 4-methyl-pyridine, contains a penta-dentate (pyrrole)(2)dien ligand furnishing an N(5) set, such that two of the pyrrole N atoms and two of the dien N atoms occupy the equatorial position...
متن کاملFormation of Methyl Sterols in Brain Cholesterol Biosynthesis STEROL FORMATIOD: IAl- VITRO ASD IX VIVO IN ADULT RAT BRAIX* (Received for publication, May 6, 19il)
A detailed study was made of methyl sterols involved in cholesterol biosynthesis in adult brain following intracerebral injection of [ZJ4C]mevalonic acid and incubation of this cholesterol precursor with adult brain cell-free preparations. High specific activity lanosterol, 4,4-dimethyl-&-cholestaS(9)-24-dien-3P-01, 4a-methyl-5a-cholesta-‘7,24-dien-3/3-o1, and Sa-cholesta-7,24-dien-3/?-ol were ...
متن کاملAnti-human immunodeficiency virus-1 protease activity of new lanostane-type triterpenoids from Ganoderma sinense.
Five new highly oxygenated lanostane-type triterpenoids [ganoderic acid GS-1 (1), ganoderic acid GS-2 (2), ganoderic acid GS-3 (3), 20(21)-dehydrolucidenic acid N (4) and 20-hydroxylucidenic acid A (5)] were isolated from the fruiting body of Ganoderma sinense, together with known compounds including 6 triterpenoids and 3 sterols. The structures of the new triterpenoids determined by spectrosco...
متن کامل